We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
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