We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
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Most Useful Reviews
9
Pain relief
11 people found this helpful
I’m glad I bought this. Nearing 60, I’ve experienced chronic fatigue syndrome, muscle fatigue, and pain. After taking it with ADAM and Omega 3, my pain and numbness disappeared. It genuinely works, and I slept well.
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9
Enhanced alertness
11 people found this helpful
Drinking this in the morning banishes my sluggishness! It’s an affordable option compared to others for combating chronic fatigue syndrome. It makes me feel alert instantly, and my atopic dermatitis has improved significantly.
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10
Increased energy
10 people found this helpful
Carnosine was prescribed for my chronic fatigue syndrome. Taking it three times daily has remarkably boosted my energy and vigour. I feel rejuvenated!
We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 103 Reviews
7.5
All Reviews
Positive Reviews
Negative Reviews
9
Pain relief
11 people found this helpful
I’m glad I bought this. Nearing 60, I’ve experienced chronic fatigue syndrome, muscle fatigue, and pain. After taking it with ADAM and Omega 3, my pain and numbness disappeared. It genuinely works, and I slept well.
Read More
9
Enhanced alertness
11 people found this helpful
Drinking this in the morning banishes my sluggishness! It’s an affordable option compared to others for combating chronic fatigue syndrome. It makes me feel alert instantly, and my atopic dermatitis has improved significantly.
Read More
10
Increased energy
10 people found this helpful
Carnosine was prescribed for my chronic fatigue syndrome. Taking it three times daily has remarkably boosted my energy and vigour. I feel rejuvenated!
Read More
9
Improved endurance
10 people found this helpful
It works wonders! My chronic fatigue syndrome feels more manageable; I can now wake up easier and have increased endurance. I noticed results after just 10 days of taking 3 capsules daily.
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9
Reduced fatigue
10 people found this helpful
I purchased this for chronic fatigue syndrome after reading about carnosine's benefits. I was amazed at how refreshed I felt the next morning. Unlike other supplements, this one truly makes a difference.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
L-Carnosine is a naturally occurring dipeptide composed of two amino acids, beta-alanine and L-histidine. It is primarily found in high concentrations in muscle and brain tissues, where it plays a role in various biological functions. L-Carnosine is known for its potential antioxidant properties, helping to protect cells from oxidative stress and damage caused by free radicals. Additionally, it is believed to have a buffering effect on pH levels in muscles, which may enhance athletic performance and delay fatigue during intense exercise.
Research surrounding L-Carnosine has suggested it may contribute to healthy aging by promoting cellular function and reducing age-related decline. Some studies indicate that it could support cognitive function and may even have potential benefits for conditions such as Alzheimer’s disease. However, it's important to note that while L-Carnosine can be obtained through dietary sources, supplementation and its effects should be approached with caution, as more research is necessary to fully understand its benefits and any potential interactions with other medications. If you're considering adding L-Carnosine to your health regimen, consulting with a healthcare professional is advisable.
Based on user reviews, the timeline for experiencing results from this supplement can vary significantly. Several users report noticeable improvements in their chronic fatigue syndrome symptoms within just a few days. For instance, one reviewer noted an increase in energy and reduced fatigue after only three days of taking the supplement Read Review. Another user mentioned feeling revitalized and more willing to engage in physical activity after just one pill at night Read Review.
Conversely, some users experienced a more gradual improvement, with one indicating that significant benefits were felt after approximately ten days of consistent use Read Review. Overall, while initial effects may be felt shortly after starting, many users recommend giving the supplement a couple of weeks to fully appreciate its potential benefits in alleviating symptoms of chronic fatigue syndrome.
L-Carnosine has been investigated as a potential treatment for conditions associated with chronic fatigue, notably in a study involving individuals with Gulf War Illness (GWI). This study utilized a randomized controlled trial design that included 25 participants who received varying doses of L-Carnosine over a 12-week period. While the results indicated some improvement in cognitive function—evidenced by higher scores on cognitive assessment tests—the supplement did not significantly alleviate the core symptoms of fatigue, pain, or overall activity levels among the participants [1].
In conclusion, while L-Carnosine may offer some cognitive benefits, it does not appear to effectively address the primary debilitating symptoms of chronic fatigue and related conditions. This suggests that individuals seeking relief from chronic fatigue syndrome may want to consider other treatment options alongside traditional approaches, as L-Carnosine’s efficacy in this area remains unproven. As always, consulting with a healthcare provider is recommended before starting any new supplement regimen.
Based on user reviews, many individuals report significant improvements in symptoms associated with chronic fatigue syndrome after taking L-Carnosine. Users have noted enhancements in energy and overall vitality, with some experiencing remarkable shifts within days of starting the supplement. For instance, one user in their 50s mentioned that after taking just one pill at night, their fatigue diminished quickly, leading to an increased willingness to engage in activities Read Review. Another reviewer specifically highlighted a boost in energy levels and an improved ability to manage daily tasks, describing their chronic fatigue syndrome as feeling "more manageable" after just ten days of use Read Review.
Furthermore, several users noted that L-Carnosine helped alleviate associated symptoms like brain fatigue and muscle pain while also offering cognitive benefits, including enhanced mental clarity Read Review. This aligns with reports from those who found it effective in supporting physical performance, with one individual noting improved recovery times and reduced post-exercise fatigue Read Review. While positive experiences are common, it's essential to remember that individual results can vary, and what works for one person may not elicit the same response in another.
Users have shared positive experiences regarding the combination of L-Carnosine with other supplements to manage Chronic Fatigue Syndrome (CFS). One reviewer reported that taking L-Carnosine alongside ADAM and Omega 3 significantly alleviated their muscle fatigue and pain, leading to noticeable improvements in their overall well-being Read Review. Additionally, another user mentioned that blending L-Carnosine with taurine helped them effectively manage both head and body fatigue, indicating that such combinations may enhance the supplement's efficacy in tackling CFS symptoms Read Review.
Others have also attested to the benefits of pairing L-Carnosine with different supplements or dietary practices. For instance, some users noted that while L-Carnosine aids in reducing fatigue and enhancing recovery, it synergizes well with their existing supplement routines, improving overall physical performance and energy levels Read Review. While individual experiences vary, the accumulation of user feedback supports the idea that combining L-Carnosine with other supplements could yield powerful results in the fight against chronic fatigue syndrome.
Users report a range of doses when using L-Carnosine to manage Chronic Fatigue Syndrome, with many finding success at different daily intake levels. For instance, one user noted taking three capsules daily, which they credited for a significant energy boost and a feeling of rejuvenation Read Review. Another user also highlighted the effectiveness of taking three capsules a day, stating they noticed results in just ten days Read Review.
Additionally, users have reported benefits from taking as little as one or two capsules a day; a user mentioned taking one at night to alleviate fatigue, leading to a remarkable improvement in their energy levels Read Review. Overall, while there isn't a one-size-fits-all dosage, the common theme from user reviews suggests that daily doses ranging from one to three capsules can be effective in alleviating the symptoms of Chronic Fatigue Syndrome.
7.5
Vision improvement
51 people found this helpful
Being in my early 50s and suffering from irritable bowel syndrome, I searched for a supplement to support my autonomic nerves and found L-Carnosine. Initially, I didn't notice any dramatic changes, but after three days, my eyesight improved significantly, allowing me to drive without glasses. I feel less fatigued, which also seems to boost my mood. Despite still having IBS and tinnitus, I'm committed to taking this supplement due to my overall enhanced physical condition.
9
Fatigue relief
I'm a woman in my 50s struggling with chronic fatigue syndrome daily. After taking one pill at night, my fatigue faded quickly, and I felt more willing to move. This supplement has been a saviour for me.
9
Improved endurance
10 people found this helpful
It works wonders! My chronic fatigue syndrome feels more manageable; I can now wake up easier and have increased endurance. I noticed results after just 10 days of taking 3 capsules daily.
9
Boosted energy
1 people found this helpful
I turned to carnosine to improve my well-being and support my body. After several days, I noticed enhanced energy and reduced chronic fatigue syndrome symptoms, leading to a notable improvement in my mental clarity.
9
Endurance increase
Athletes have benefited from L-Carnosine in managing chronic fatigue syndrome. It significantly boosts muscle endurance, reduces fatigue and muscle pain post-exercise, and accelerates recovery from injuries.
9
Pain relief
11 people found this helpful
I’m glad I bought this. Nearing 60, I’ve experienced chronic fatigue syndrome, muscle fatigue, and pain. After taking it with ADAM and Omega 3, my pain and numbness disappeared. It genuinely works, and I slept well.
9
Fatigue elimination
3 people found this helpful
This supplement is fantastic for combating body and head fatigue! It refreshes me significantly, especially when taken with taurine. I intend to remain diligent in taking it regularly, as it helps me manage my chronic fatigue syndrome effectively.
9
Enhanced athletic performance
3 people found this helpful
Since incorporating L-Carnosine into my diet, I've seen notable improvements in my athletic performance. It supports my active hiking and workout routine, increasing my stamina and reducing post-activity fatigue. This has considerably sped up my recovery time and has been a reliable aid in managing my chronic fatigue syndrome.
10
Increased energy
10 people found this helpful
Carnosine was prescribed for my chronic fatigue syndrome. Taking it three times daily has remarkably boosted my energy and vigour. I feel rejuvenated!
4
L-carnosine shows limited benefits
Carnosine treatment for gulf war illness: a randomized controlled trial.
We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
References
Baraniuk JN, El-Amin S, Corey R, Rayhan R, Timbol C. Carnosine treatment for gulf war illness: a randomized controlled trial. Glob J Health Sci. 2013;5:69. doi:10.5539/gjhs.v5n3p69